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10:4511:00 17. Nov 2021
10:4511:00 17. Nov 2021 iCal myOrganizer

MLF: Accessing the repertoire of SARS-CoV-2 specific CD8+ T cell receptors

Session Diversity at its best

The talk will explain the experimental tools used to study qualitative T cell responses to SARS-CoV-2 infection. Immunodominant epitopes triggering strong CD8+ T cell responses in convalescent mild COVID-19 were identified. State of the art technologies of scRNA-seq give access to the repertoire of T cells specific for identified epitopes. T cell engineering validates TCR functionality and shows effective cytotoxicity towards virus-infected target cells, which is crucial for protective immunity.