MLF: A CRISPR discovery enables multiplexed RNA detection

Session Next-generation biosensing

Vorsitzende

Dr. Peter Quick Association of the Diagnostics Industry (VDGH e.V.), Life Science Research Department (FA LSR)

SprecherInnen

Prof. Dr. Chase Beisel Helmholtz Institute for RNA-based Infection Research, Professor and Group Leader, RNA Synthetic Biology

CRISPR is best known for genome editing, yet it represents widespread immune systems in bacteria. Here, I'll describe a new discovery we made regarding the biology of these systems and how it lends to multiplexed RNA detection. I'll then show how this platform can be applied for multiplexed in vitro diagnostics and transcriptional recording in live cells. These capabilities expand the repertoire of CRISPR technologies and could open new avenues for the accurate diagnosis of human disease.